Fig. 6From: Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s DiseaseW20/XD4-SPIONs rescued synapse loss in the brains of AD mice. The PSD-95 immunostaining (a) and synaptophysin immunostaining (b) in the brains of WT and AD mice treated with various SPIONs. Scale bar 10 μm. (c) Quantification of PSD-95 and synaptophysin immunostaining in the cortex and hippocampal regions. n = 8 mice/group. Data represent means ± SEM and were analyzed by one-way ANOVA with Tukey’s test. *P < 0.05, **P < 0.01, ***P < 0.001Back to article page