Skip to main content
Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Nanoparticle-complexed antimiRs for inhibiting tumor growth and metastasis in prostate carcinoma and melanoma

Fig. 6

Treatment of distant melanoma metastases with antimiR/PEI complexes in mice. a,b For the analysis of anti-metastatic effects of PEI/antimiR-mediated inhibition, 5 × 106 LOX melanoma cells were injected intravenously into the tail veins of NOD scid gamma mice. After 7 days, mice were randomized into specific treatment groups (antimiR-150, antimiR-638 and scrambled RNA). The PEI/antimiR complexes were injected intraperitoneally every 2 days. Lungs will be surgically removed after 4 weeks and lung metastasis was evaluated by counting of number of melanoma metastatic lesions in representative sections of each lung and the number of affected lungs. The total number of metastases per group and number of affected lung samples is given as bar graphs. c Representative examples of metastatic lesions in mouse lungs (arrows)

Back to article page