Nebulised surface-active hybrid nanoparticles of voriconazole for pulmonary Aspergillosis demonstrate clathrin-mediated cellular uptake, improved antifungal efficacy and lung retention

Table 3 Values of minimum inhibitory concentration (MIC) of voriconazole (VRC) and lipid polymer hybrid nanoparticles against different fungal strains

Type of strain	Fungal strain	Labortory I.D.	MIC (µg. mL⁻¹)
Type of strain	Fungal strain	Labortory I.D.	VRC	Blank LPH NPs	Drug loaded LPH NPs
Laboratory strains	Candida krusei	CK 6258	0.23	14.84	0.11
	Candida parapsilosis	CP 22,019	0.05	14.84	0.03
	Aspergillus flavus	ATCC 204304	0.92	14.84	0.46
	Aspergillus fumigatus	ATCC 204305	0.92	14.84	0.23
Clinical isolates	Aspergillus flavus	R 4443	0.92	14.84	0.92
	Aspergillus fumigatus	R 4322	0.92	14.84	0.92
	Aspergillus fumigatus	R 4784	0.92	14.84	0.92

ISSN: 1477-3155