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Table 5 Stability study data for freeze-dried hybrid nanoparticles of voriconazole

From: Nebulised surface-active hybrid nanoparticles of voriconazole for pulmonary Aspergillosis demonstrate clathrin-mediated cellular uptake, improved antifungal efficacy and lung retention

Parameters Zero day After 30 days After 90 days
5 ± 3 °C 25 ± 2 °C/60 ± 5% RH 40 ± 2 °C/75 ± 5% RH 5 ± 3 °C 25 ± 2 °C/60 ± 5% RH 40 ± 2 °C/75 ± 5% RH
PS (nm) 270.2 ± 17.3 273.2 ± 21.14 278.6 ± 33.02 405.9 ± 31.75 282.8 ± 30.11 478.3 ± 40.85 531.5 ± 37.89
PDI 0.312 ± 0.012 0.373 ± 0.018 0.389 ± 0.047 0.431 ± 0.194 0.349 ± 0.024 0.580 ± 0.104 0.871 ± 0.117
EE (%) 52.25 ± 2.72 51.72 ± 2.81 49.34 ± 3.01 43.92 ± 3.57 50.43 ± 3.91 44.84 ± 3.48 36.67 ± 4.59
  1. PS Particle size, PDI polydispersity index, EE Entrapment efficiency