Nebulised surface-active hybrid nanoparticles of voriconazole for pulmonary Aspergillosis demonstrate clathrin-mediated cellular uptake, improved antifungal efficacy and lung retention

Table 5 Stability study data for freeze-dried hybrid nanoparticles of voriconazole

Parameters	Zero day	After 30 days			After 90 days
Parameters	Zero day	5 ± 3 °C	25 ± 2 °C/60 ± 5% RH	40 ± 2 °C/75 ± 5% RH	5 ± 3 °C	25 ± 2 °C/60 ± 5% RH	40 ± 2 °C/75 ± 5% RH
PS (nm)	270.2 ± 17.3	273.2 ± 21.14	278.6 ± 33.02	405.9 ± 31.75	282.8 ± 30.11	478.3 ± 40.85	531.5 ± 37.89
PDI	0.312 ± 0.012	0.373 ± 0.018	0.389 ± 0.047	0.431 ± 0.194	0.349 ± 0.024	0.580 ± 0.104	0.871 ± 0.117
EE (%)	52.25 ± 2.72	51.72 ± 2.81	49.34 ± 3.01	43.92 ± 3.57	50.43 ± 3.91	44.84 ± 3.48	36.67 ± 4.59

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