Fig. 3

The therapeutic effect of Dox delivered in silk spheres in Her2(+) and Her2(−) mouse orthotopic breast cancer models. a Schematic representation of the treatment course. Mice were injected with PBS, free Dox, and Dox-loaded spheres (Dox dose = 5 mg/kg). b Kinetics of tumor growth during treatment in a Her2(+) breast cancer model. c The D2F2E2 tumors were excised 20 days after the beginning of the treatment, as indicated in b. d Kinetics of tumor growth during treatment in a Her2(−) breast cancer model. e The D2F2 tumors were excised 20 days after the beginning of the treatment, as indicated in d. The data presented are expressed as the means ± SEM; *** p < 0.001, ns not significant