Fig. 4

The impact of the number of treatment administrations on the therapeutic effect of Dox delivered in silk spheres in a Her2(+) orthotopic breast cancer model. a Schematic representation of the treatment course. Mice were injected with PBS, free Dox, and Dox-loaded spheres (Dox dose = 5 mg/kg). b Whole-body IVIS luminescent images of D2F2E2 tumor-bearing mice obtained using the IVIS Spectrum. c Kinetics of tumor growth during treatment. d The D2F2E2 tumors were excised 20 days after the beginning of the treatment. e Weight of D2F2E2 tumor-bearing mice during treatment. The data presented are expressed as the means ± SEM; *** p < 0.001, * p < 0.05