Fig. 7

Histological analysis of tumors that developed in an orthotopic breast cancer model. H&E staining of tumor sections from D2F2E2 tumor-bearing mice after 20 days of treatment with a PBS and b 20 mg of Dox/kg b.w. loaded in H2.1MS1 particles, according to the schedule presented in Fig. 5a. On the left and in the middle: analysis of necrotic and degenerative cells at two different magnifications, 4X and 10X, respectively. On the right: analysis of mitosis. Black arrows indicate degenerative cells; white arrows—necrosis; green arrows—mitosis. Scale bars: 200 µm, 50 µm, and 20 µm