Fig. 8

Biodistribution of silk spheres in a Her2(+) model of metastatic breast cancer. a Schematic representation of the treatment course. b Biodistribution of the control MS1 and H2.1MS1 spheres in the lungs on the 17th day after the first intravenous injection. The lungs were excised and imaged. Signal detection was performed by using the IVIS Spectrum at excitation/emission wavelengths of 640/680 nm. c Biodistribution of ATTO647N-labeled MS1 and H2.1MS1 spheres over time. Whole-body IVIS fluorescent images were obtained using the IVIS Spectrum