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Table 1 Histopathological analysis of tumors developed in a metastasis model of breast cancer

From: Functionalized silk spheres selectively and effectively deliver a cytotoxic drug to targeted cancer cells in vivo

 

D2F2E2

D2F2

PBS

MS1

H2.1MS1

PBS

MS1

H2.1MS1

Metastasis index

0.730 (± 0.848)

1.197 (± 1.068)

0.078 (± 0.106)

30.653 (± 19.09)

19.063 (± 14.236)

31.867 (± 23.336)

Number of mitoses (5HPF-40X)

26 (± 4)

11 (± 2) *

ND

46 (± 13)

34 (± 18)

26 (± 11)

Degree of apoptosis

1

1

ND

2

1.66

(± 0.58)

2.3

(± 0.58)

Necrosis index

0

0

ND

8.983 (± 2.309)

1.083 *** (± 0.553)

5.197 (± 4.375)

% of degenerative cells

0.533 (± 0.681)

4.533 (± 3.579)

ND

0.167 (± 0.289)

5.933 (± 5.198)

4.733 (± 4.248)

  1. H&E-stained lung tissue sections from mice injected with Her2(+) cells and Her2(−) cells were characterized according to the histopathological classification. The data are presented as the means of 3 specimens ± SD; *** p < 0.001, * p < 0.05
  2. ND not determined