Fig. 7
Verification of CCM@MSNs-ISOIM targeting and its anti-tumor effect in vivo. A The fluorescence images in vivo were observed at 6 h, 24 h and 48 h after MSNs-Cy5 and CCM@MSNs-Cy5, respectively, were injected into the tail vein of OCI-LY10 tumor-bearing mice. B MSNs-Cy5 and CCM@MSNs-Cy5 were given to the caudal vein respectively, and the fluorescence imaging of the tumor tissue of tumor-bearing mice was observed for 48 h. Scale bar: 50 μm. C Curve changes of tumor volume in OCI-LY10 tumor-bearing mice during treatment. D Different treatments were given to the caudal vein, and the H&E staining images of tumor tissues were observed on the 21st day. Scale bar: 50 μm. E, F Ki-67 and TUNEL were detected on the 21st day after a) PBS, b) ISOIM, c) MSNs@ISOIM and d) CCM@MSNs-ISOIM treatment by tail vein, respectively. Scale bar: 20 μm. Data are presented as the mean ± SD (n = 3). (* p < 0.05)