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Table 1 List of predicted mRNA targets of the miRNAs

From: Improvement of stem cell-derived exosome release efficiency by surface-modified nanoparticles

miRNA Predicted target mRNA Functions and characteristics Database on ExoCerta
Symbol Full name
mmu-miR-2137 Gpx4 Glutathione peroxidase 4 Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation o
Gosr1 Golgi SNAP receptor complex member 1 Regulates intracellular reactive oxygen species levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13, and MAPK14) o
Rab4A Ras-related protein Rab-4A Protein transport. Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling o
Prrx1 Paired related homeobox 1 Enhances DNA-binding activity, and induces genes by growth and differentiation factors Unknown
Pex26 Peroxisomal biogenesis factor 26 Peroxisome biogenesis factor 1, also known as PEX1 Unknown
mmu-miR-3473b Rspry1 Ring finger and SPRY domain containing 1 Extracellular region and zinc ion binding o
Ephb2 Eph receptor B2 Encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins o
Cplx2 Complexin 2 Refers to one of a small set of eukaryotic cytoplasmic neuronal proteins that binds to the SNARE protein complex (SNAREpin) with high affinity o
Il-7 Interleukin 7 IL-7 stimulates the differentiation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells o
Rab11fip1 RAB11 family interacting protein 1 Forms a targeting complex that recruits a group of proteins involved in membrane transport to organelles o
mmu-miR-3473e St6galnac6 ST6-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 Modifies ceramides on the cell surface to alter cell–cell or cell-extracellular matrix interactions o
Adcy1 Adenylate cyclase 1 Regulates various cellular functions via activating protein kinase A-dependent phosphorylation o
Wnk2 Serine/threonine-protein kinase WNK2 Plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation o
Sioa1l3 Signal-induced proliferation-associated 1-like protein 3 Plays a critical role in epithelial cell morphogenesis, polarity, and adhesion and cytoskeletal organization in the lens Unknown
mmu-miR-5126 Atp6v1c2 V-type proton ATPase subunit C 2 Subunit of the peripheral V1 complex of vacuolar ATPase o
CD4 CD4 molecules Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses o
Pax2 Paired box 2 Has a critical role in the development of the urogenital tract, the eyes, and the central nervous system Unknown
Aire Autoimmune regulator Expressed by a distinct bone marrow-derived population; induces self-tolerance through a mechanism that does not require regulatory T-cells and is resistant to innate inflammatory stimuli Unknown
mmu-miR-455-3p Tti1 TELO2-interacting protein 1 homolog Phosphorylated at Ser-823 by CK2 following growth factor deprivation, leading to its subsequent ubiquitination by the SCF (FBXO9) complex o
Hk3 Hexokinase 3 HK3 functions to protect the cell against apoptosis. Overexpression of HK3 has resulted in increased ATP levels, decreased reactive oxygen species production, attenuated reduction in the mitochondrial membrane potential, and enhanced mitochondrial biogenesis o
Sar1a Secretion associated Ras-related GTPase 1A Involved in membrane trafficking. It is a monomeric small GTPase found in COPI vesicles. It regulates the assembly and disassembly of COPII coats o
Fgf4 Fibroblast growth factor 4 Possesses broad mitogenic and cell survival activities and is involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, and tissue repair Unknown
Pex5 Peroxisomal biogenesis factor 5 Targeting sequence involved in the specific transport of molecules for oxidation inside the peroxisome Unknown
mmu-miR-877-5p Gpx1 Glutathione peroxidase 1 Belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide by glutathione and, thereby, protects cells against oxidative damage o
Aak1 AP2 associated kinase 1 Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2), which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis Unknown
Wnk3 WNK lysine deficient protein kinase 3 Plays a role in the increase of cell survival in a caspase 3-dependent pathway as a positive regulator of the transcellular Ca2+ transport pathway Unknown
Rab26 RAB26, member RAS oncogene family Important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling Unknown
Sult1e1 Sulfotransferase family 1E, member 1 Catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds Unknown
mmu-miR-149-3p Apoc2 Apolipoprotein C-II Extracellular region or secreted. Hydrolyzes triglycerides and thus provides free fatty acids for cells o
Rab11fip5 Rab11 family interacting protein 5 Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane Unknown
Leng8 Leukocyte receptor cluster member 8 Predicted using known transcription factor binding site motifs Unknown
Galnt17 Polypeptide N-acetylgalactosaminyl transferase 17 Serve a variety of structural and functional roles in membrane and secreted proteins Unknown