|
SiO2-NPs
|
In vitro
|
Human intestinal CaCo-2 cells exposed to quartz, SiO2-55 nm or SiO2-15 nm at 4, 16, 32 and 64 μg/mL or 15 nm at 64 μg/mL for 24 h
|
Increase in ɣ-H2AX
|
[56]
|
|
TiO2-NPs
|
In vitro
|
Human lung adenocarcinoma epithelial cells A549 exposed to 50-1000 µg/mL or 1-100 µg/mL TiO2-NPs for 1, 24, and 48 h
|
Increase in ɣ-H2AX independent of oxidative stress
|
[51]
|
|
TiO2 -NPs and Nano-cobalt (Nano-Co)
|
In vitro
|
Human lung adenocarcinoma epithelial cells A549, exposed to 5-15 µg/mL TiO2-NPs and nano-Co for 12 h
|
Increase in ɣ-H2AX
|
[52]
|
|
TiO2-NPs
|
In vitro
|
Human lung adenocarcinoma epithelial cells A549, macrophage-likeTHP-1 cells, and human pulmonary microvascular endothelial cells HPMEC-ST1.6R were exposed to 5, 200, and 800 µg/mL TiO2-NPs for 4 and 24 h
|
Increase in ɣ-H2AX in THP-1 and HPMEC-ST1.6R cells
|
[53]
|
|
TiO2-NPs
|
In vitro
|
Human dermal fibroblasts isolated from neonatal foreskins, exposed to 100, 30, 10, 3, and 1 µg/mL TiO2-NPs for 24 h
|
Increase in ɣ-H2AX
|
[54]
|
|
TiO2 -NPs
|
In vitro
|
Human skin fibroblasts cell line (BJ), exposed to 10, 25, 50, 100, 250, 500, and 1000 µg/mL TiO2-NPs for 24 h
|
Increase in ɣ-H2AX
|
[55]
|
|
Ag-NPs
|
In vitro
|
Human lung adenocarcinoma epithelial cells A549, exposed to 10-200 µg/mL Ag-NPs for 48 and 72 h
|
Increase in ɣ-H2AX
|
[35]
|
|
Ag-NPs
|
In vitro
|
Human skin keratinocytes (HaCaT), human lung (A549) and human breast adenocarcinoma cells (MCF-7) treated with 1.0 µg/mL Ag-NPs for 4 h
|
Increase in ɣ-H2AX in A549 and MCF-7 cells.
|
[50]
|
|
Au-NPs
|
In vitro
|
Human MDA-MB-231 and MDA-MsB-468 breast cancer cells exposed to 100, 250, and 500 µg/mL positively (+) and to 250 and 500 µg/mL negatively (-) charged Au-NPs for 24 h
|
Increase in ɣ-H2AX
|
[57]
|
|
CuO-NPs
|
In vitro
|
Human hepatocellular carcinoma cells HepG2 (well-differentiated) and SK-Hep-1 (poorly differentiated) were exposed to Cu-NPs at 0, 10, 25, 50, 75, and 100 µg/mL for 24 h
|
Increase in ɣ-H2AX, especially in SK-Hep-1 cells, in dose–dependent manner
|
[58]
|
|
Cerium dioxide NPs (CeO2-NPs)
|
In vitro
|
Human peripheral blood lymphocytes were exposed to CeO2-NPs at 6, 12, and 18 µg/mL for 3-24 h
|
Increase in ɣ-H2AX
|
[59]
|
|
Arsenic trioxide NPs (As2O3-NPs)
|
In vitro
|
Human embryonic kidney HEK293 or HeLa cells were exposed to As2O3-NPs at 0.2–0.8 µM for 24, 48, and 72 h
|
Increase in ɣ-H2AX
|
[60]
|
|
ZnO-NPs
|
In vivo and in vitro
|
Chickens fed diets containing ZnO-NPs at 10–200 mg/kg for 24 weeks, then artificially inseminated, embryonic development monitored, and ovarian cells cultured
|
Increase in ɣ-H2AX
|
[61]
|
|
Iron oxide nanoparticles (S-ION) silica coated
|
in vitro
|
Human A-172 glioblastoma cells exposed to various concentration of S-ION (5-100 µg/ml) for 3 and 24 h
|
Increase in H2AX at 50 and 100 µg/ml S-IOP for 24 h
|
[62]
|
