|Nanoparticles (NPs) and Nanomaterials (NMs)||In vitro or in vivo||Experimental design||Epigenetic effect||Reference|
|SiO2-NPs||In vitro||Mouse Bhas 42 cells exposed to 15 or 25 µg/cm2 of the crystalline silica particles Min-U-Sil® 5 for 48 h||
Increase in H3K4ac, H3K4me3, H3K9ac, H3K27ac|
Increase in HDAC2.
Decrease in HDAC1, HDAC6
|SiO2-NPs||In vitro||Human A549 cells exposed to 50.0 µg/mL SiO2-NPs for 3-12 h||Decreased levels of SIRT6 histone deacetylase (HDAC) transcript and protein|||
|TiO2 –NPs||In vitro||Human dermal fibroblasts isolated from neonatal foreskins, exposed to 100, 30, 10, 3, and 1 µg/mL TiO2 -NPs for 24 h||Increase of ATM, and Chk2 phosphorylation|||
|TiO2 -NPs||In vitro||Human adipose delivered stem cells (hASCs) exposed to 70 nm TiO2–nanotubes||
Increase of H3K4 methylation at the promoter region of osteogenic genes RUNX2 and osteocalcin (OC)|
Inhibition of histone demethylate
|Au-NPs||In vitro||Human MDA-MB-231 and MDA-MsB-468 breast cancer cells exposed to 100, 250, and 500 µg/mL positively (+) and to 250 and 500 µg/mL negatively (-) charged Au-NPs for 24 h||
Activation of MAP kinases in MDA-MB-231 cells|
Increase in MKP-1 protein in (-) AU-NPs in both cell lines
Decrease in MKP-1 protein levels by (+) charged Au-NPs.
Deacetylation of histone H3K9/H3K14
Dephosphorylation of histone H3Ser10 at 250 µg/mL negatively charged Au-NPs.
Increase in H3K9/H3K14 acetylation at all doses of positively charged Au-NPs.
|Au-NPs||In vitro||Small airway epithelial cells exposed to 20 nm Au-NPs for 72 h||Decrease in H3K27me3|||
|Arsenic trioxide NPs (As2O3-NPs)||In vitro||Human embryonic kidney (HEK) 293T or HeLa cells were exposed to As2O3-NPs at 0.2- 0.8 µM for 24, 48, and 72 h||Decrease in global H4K16ac|||
|Ag-NPs||In vitro||Human A549, MCF7, and HaCat cells exposed to 0.3 µg/mL Ag-NPs for 24 h||Increase in histone 3 serine 10 phosphorylation (H3S10ph)|||
|Ag-NPs||In vitro||Human lung adenocarcinoma epithelial cells A549, exposed to 1.0 µg/mL Ag-NPs for 10 h||Increase of histone H3 serine 10 phosphorylation (H3S10ph) independent of DNA damage|||
|Ag-NPs||In vitro||Human lung adenocarcinoma epithelial cells A549, exposed to 10-200 µg/mL Ag-NPs for 48 and 72 h||
Deacetylation of histone H3 tails and elevation of total histone H3|
Phosphorylation of p53
|Ag-NPs||In vitro||Mouse erythroleukemia cells exposed to 8 µg/mL Ag-NPs for 72 h||Decrease in global and β-globin specific histone H3 lysine 4 trimethylation (H3Kme3) and histone H3 lysine 79 monomethylation (H3K79me1)|||
|CuO-NPs||In vitro||Human A549 cells exposed to CuO-NPs for 36 h||
Decrease of total HDAC activity.|
Reduction in the levels of HDAC1, HDAC2, HDAC3, HDAC5, HDAC9, and HDAC11 mRNA transcripts.
|Zinc oxide nanoparticles (ZnO-NPs)||In vitro||HaCaT cells exposed to 20 and 50 µg/mL ZnO-NPs for 24 h||
Deacetylation of histone H4 lysine 5 (H4K3)|
Increased demethylation of histone H3 lysine 9 (H3K9)
Increased expression of G9a and GLP histone methyltransferase genes
Down-regulation of GCN5, P300, and CBP histone acetyltransferase genes
|ZnO-NPs||In vitro||Human bladder cancer T24 cells exposed to 10 µg/mL ZnO-NPs for 48 h||Decrease of global histone 3 lysine 27 trimethylation (H3K27me3) at the RUNX3 gene promoter|||
|Arsenic trioxide nanoparticles (As2O3-NPs)||In vitro||Human embryonic kidney (HEK) 293T or HeLa cells were exposed to As2O3-NPs at different concentrations (0.2 ~ 0.8 μM) for 24, 48, or 72 h||
Reduction of global histone 4 lysine 16 acetylation (H4K16ac)|
Increase of deacetyltransferase HDAC4 expression
|Nano-cobalt (Nano-Co) and TiO2 -NPs||In vitro||Human lung adenocarcinoma epithelial cells A549, exposed to 5-15 µg/mL TiO2 -NPs and Nano-Co for 12 h||Increased expression of Rad51, and phosphorylated p53|||
|Cadmium telluride quantum dots (CdTe-QDs)||In vitro||Human breast cancer cells MCF-7 were exposed to 5 μg/ml CdTe-QDs for 4 or 24 h||Global histone hypoacetylation|||