Fig. 5
From: Synergy of hypoxia relief and heat shock protein inhibition for phototherapy enhancement
Biodistribution of IGM in vivo. a Dynamic fluorescence images of IGM (IR780, 120 μg/ml) in 4T1 tumor-bearing mice at different time points after intravenous injection. b Ex vivo NIR fluorescence images and c quantitation of major organs and tumor at 48 h after IGM treatment (n = 3, **P<0.01, tumor vs. other organs). d The increased temperature of tumor at 24 h post injection with laser irradiation(n = 3, **P<0.01, IGM vs. saline). e Immunofluorescence images of tumor slices stained by HIF-1α after intravenous injection of IGM at 0 h and 24 h. Data are expressed as mean ± SD (n = 3)