Fig. 3

The targeting capability of Au-DOX@PO-ANG in vitro. a Illustration of polymersomes crossing the BBB model established using primary astrocytes and cerebral microvascular endothelial cells. b The TEER value of BBB models. c The permeability coefficient of sodium fluorescein in BBB models,**P < 0.01 compared with BMECs group. d The in vitro BBB model transport ratios (%) of Au-DOX@PO and Au-DOX@PO-ANG following 24 h of incubation, blockade experiments were conducted by pretreating U87-MG cells with free ANG (100 μg/mL, 30 min) before Au-DOX@PO-ANG incubation