Fig. 5
Pharmacokinetics and therapeutic efficiency of BsAbs plus PLD. a BALB/c mice were intravenously injected with 1 mg kg−1 PEG BsAb (black circles) or DNS BsAb (white circles). Mean plasma concentrations of the BsAbs were measured by sandwich ELISA (n = 3 mice). Data are shown as mean ± SD. n = 3. b Groups of eight SCID mice bearing Raji cells were intravenously injected with 1 mg kg−1 PEG BsAb plus 2 mg kg−1 PLD (blue circles), 1 mg kg−1 DNS BsAb plus 2 mg kg−1 PLD (red squares), 1 mg kg−1 PLD (green triangles), 1 mg kg−1 PEG BsAb (purple triangles) or PBS (yellow diamonds). Results are presented as means (n = 8). PEG BsAb, CD20 Ab-mPEG scFv; DNS BsAb, CD20 Ab-DNS scFv; PLD, PEGylated liposomal doxorubicin. Data are shown as mean ± SD. n = 8