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Fig. 7 | Journal of Nanobiotechnology

Fig. 7

From: Graphene-modified CePO4 nanorods effectively treat breast cancer-induced bone metastases and regulate macrophage polarization to improve osteo-inductive ability

Fig. 7

a CCK-8 assays of MC3T3-E1 cells cultured in the extracts of different scaffold materials for different days. b SEM images of hBMSCs co-cultured on CS, CePO4/CS and CePO4/CS/GO scaffolds. c, d ALP staining and alizarin red staining images of MC3T3-E1 cells cultured in the extracts of CS, CePO4/CS and CePO4/CS/GO scaffolds for 7 days. e RT-PCR analysis for ALP, RUNX2, BMP-2 and OCN expression of MC3T3-E1. f Western blot analysis for BMP-2, P-Smad1/5, Smad1/5, RUNX2 and COL1 of MC3T3-E1. g Micro-CT images of skulls of the control, CS, CePO4/CS, and CePO4/CS/GO groups 3 months after the surgery. h Bone volume/tissue volume (BV/TV). i Quantitative analysis of the morphology of the bone mineralization density (BMD), n = 3, *P < 0.05

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