Fig. 3

In vitro siRNA / drug release, gene silence efficacy and ultrastructural TEM images of lung tumor tissue from treated mice. a siRNA release from the Au-siRNA-PAA-AS1411 nanocages and Au-siRNA; DOX release from Au-siRNA-PAA-AS1411 nanocages; b The silencing effect of Au-siRNA-PAA-AS1411 and Au-siRNA-PAA in the lung-adenocarcinoma NCI-H889 cell line. The gene silencing efficacy reached 80% for the Au-siRNA-PAA-AS1411 group with a concentration of 10 nM Au-siRNA-PAA-AS1411 and up to 48 h of incubation (n = 3, ***P < 0.005); c, d TEM images of NCI-H889 cells incubated with 500 µg mL^− 1 Au-siRNA-PAA-AS1411 nanocages