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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Au-siRNA@ aptamer nanocages as a high-efficiency drug and gene delivery system for targeted lung cancer therapy

Fig. 4

Confocal images and cell apoptosis levels of NCI-H889 cells incubated with the Au-siRNA-PAA-AS1411 /Au-siRNA-PAA nanocages. a NCI-H889 cells incubated with 100 µg mL− 1 Au-siRNA-PAA-AS1411 for 1 h; b NCI-H889 cells incubated with 100 µg mL− 1 Au-siRNA-PAA for 1 h. Chanel 1: Fluorescence signal of Au nanocages modified with Cy5; Chanel 2: Hoechst 33,342 signal; Chanel 3: Bright field; Chanel 4: Overlapped field. Magnification: ×40; c Flow cytometric analysis of NCI-H889 cell apoptosis induced by siRNA, Au-siRNA-PAA and Au-siRNA-PAA-AS1411 with the MMP-2 enzyme at 37 °C for 24 h

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