Fig. 6

Lung cancer inhibition ratio and the survival rate of the mice. a Representative non-invasive imagings of lung-adenocarcinoma NCI-H889 tumor-bearing nude mice treated with siRNA, Au-siRNA-PAA, Au-siRNA-PAA-AS1411(no DOX) and Au-siRNA-PAA-AS1411 nanocages at days 7, 18 and 36; b Body weight change curve of tumor-bearing mice over the 36 days of treatment. c Kaplan–Meier survival curves of mice treated with siRNA (green), DOX-loaded Au-siRNA-PAA (black), DOX-loaded Au-siRNA-PAA-AS1411 (red) and Au-siRNA-PAA-AS1411 without DOX(blue). Data represent the mean ± standard deviation (n = 6, ***P < 0.005)