Fig. 5
From: Decrease in membrane fluidity and traction force induced by silica-coated magnetic nanoparticles
Transcriptome analysis in HEK293 cells treated with MNPs@SiO2(RITC) for 12 h. Heatmap of differentially expressed genes (21 genes related to lipid peroxidation (a) and 31 genes related to focal adhesion (b)) at 0.1 and 1.0 µg/µL MNPs@SiO2(RITC)-treated cells, according to microarray analysis. Red and green areas indicate up- and downregulated genes, respectively. A network of lipid peroxidation and focal adhesion-related genes was constructed algorithmically using IPA. c The transcriptome network of 1.0 µg/µL MNPs@SiO2(RITC)-treated cells and d prediction analysis for the network are shown. Red and green areas indicate up- and downregulated genes, respectively. Orange and blue colours indicate activation and suppression, respectively. Lines indicate indirect (dotted) or direct (solid) relationship. Differentially expressed genes obtained from microarray data (genes with > threefold change) are shown