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Table 3 Pharmacokinetic parameters of TMP.HCl and TAT-TMP-NPs in plasma of healthy rats after intravenous injection (n = 5)

From: TAT-modified serum albumin nanoparticles for sustained-release of tetramethylpyrazine and improved targeting to spinal cord injury

Parameters

Unit

TMP.HCl

TAT-TMP-NPs

Mean ± SD

Mean ± SD

Cmax

µg/mL

156.262 ± 3.380

109.783 ± 4.064

Tmax

h

0.083

2

AUC0 − t

µg/mL * h

454.160 ± 27.728

887.623 ± 28.530

MRT

h

2.633 ± 0.142

5.075 ± 0.095

t1/2

h

2.066 ± 0.116

7.312 ± 1.916

CL

mL/h/kg

18.200 ± 1.166

6.600 ± 1.020

Vd

mL/kg

54.200 ± 2.040

64.800 ± 5.344

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Journal of Nanobiotechnology

ISSN: 1477-3155

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