Fig. 4From: Genomic instability-derived plasma extracellular vesicle-microRNA signature as a minimally invasive predictor of risk and unfavorable prognosis in breast cancerValue of miGISig for the diagnosis of BC. Violin diagram of the miGISig miRNAs expression level in healthy controls and BC patients in TCGA-BC cohort (a), GSE73002 cohort (b) and GSE41922 cohort (c). Statistical analysis was performed using the Mann–Whitney U test. ROC curve for the performance of the miGISig in the diagnosis in the TCGA-BC cohort (d), GSE73002 cohort (e) and GSE41922 cohort (f). g Violin diagram of the miGISig miRNAs expression level in healthy controls and BC patients in the in-house clinical exosome cohort. Statistical analysis was performed using the Mann–Whitney U test. h ROC curve for the performance of miR-128 and miR-421 in the clinical exosome cohort. AUC the area under the curve, BC breast cancer, ROC area under the receiver operating characteristic curve. *P-value < 0.05, **P-value < 0.01, ***P-value < 0.001Back to article page