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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Genomic instability-derived plasma extracellular vesicle-microRNA signature as a minimally invasive predictor of risk and unfavorable prognosis in breast cancer

Fig. 5

Overexpression of miR128-1, miR128-2 and miR421 promotes genomic instability, induces an S-phase arrest and promotes the growth of breast cancer cells. QRT-PCR detection of miR128-1, miR128-2 and miR421 expression in seven breast cancer cells and normal human mammary epithelial cells 184A1 and MCF-10A (a). QRT-PCR detection of miR128-1, miR128-2 and miR421 expression transfected with miRNAs mimics in MDA-MB-231 cells (b). The percentage of multinuclei and micronuclei in MDA-MB-231 cells after overexpression of miR128-1, miR128-2 and miR421 (c). Cell cycle distribution of MDA-MB-231 cells after overexpression of miR128-1, miR128-2 and miR421 (d). Cell growth curve of MDA-MB-231 cells with miR128-1, miR128-2 and miR421 overexpression (e)

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