Core–shell nanoparticles suppress metastasis and modify the tumour-supportive activity of cancer-associated fibroblasts

Table 1 Functions of cancer-associated genes showing expressional changes in CAFs upon AgNP and Au@Ag exposures

Hit	Protein product	Role in invasion and metastasis	References
Spp1	Osteopontin	Promotes metastasis and invasion	[42,43,44]
Ptn	Pleiotrophin	High Ptn expression is correlated with metastasis, regulates cancer cell migration	[45]
Thbs1	Thrombospondin-1	Deregulation of Thbs1 promotes tumour angiogenesis and metastasis	[46, 47]
Col6a1	Collagen type VI alpha 1 chain	Col6a1 expression is associated with tumour size and metastasis	[48, 49]
Col6a2	Collagen type VI alpha 2 chain	High Col6a2 expression is correlated with poor cancer survival	[50]
Ccl7	chemokine (C-C-motif) ligand 7/monocyte-chemotactic protein 3	Tumour-associated fibroblast-driven CCL7 promotes metastasis	[51, 52]
Thbs2	Thrombospondin-2	Cancer cell-derived Thbs2 induces fibroblast activation. Thbs2 promotes bone metastasis in prostate cancer	[53, 54]
Adamts5	ADAM metallopeptidase with thrombospondin type 1 motif 5	Adamts5 overexpression regulates invasion of non-small cell lung cancer	[55, 56]
Cyr61	Cystein rich angiogenic inducer 61	Promotes tumour cell extravasation and metastasis	[57]
Ctgf	Connective tissue growth factor	Promotes osteosarcoma angiogenesis	[58]
Mmd	Monocyte to macrophage differentiation protein	Regulates tumour growth in non-small cell lung cancer	[59]

ISSN: 1477-3155