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Table 1 Functions of cancer-associated genes showing expressional changes in CAFs upon AgNP and Au@Ag exposures

From: Core–shell nanoparticles suppress metastasis and modify the tumour-supportive activity of cancer-associated fibroblasts

HitProtein productRole in invasion and metastasisReferences
Spp1OsteopontinPromotes metastasis and invasion[42,43,44]
PtnPleiotrophinHigh Ptn expression is correlated with metastasis, regulates cancer cell migration[45]
Thbs1Thrombospondin-1Deregulation of Thbs1 promotes tumour angiogenesis and metastasis[46, 47]
Col6a1Collagen type VI alpha 1 chainCol6a1 expression is associated with tumour size and metastasis[48, 49]
Col6a2Collagen type VI alpha 2 chainHigh Col6a2 expression is correlated with poor cancer survival[50]
Ccl7chemokine (C-C-motif) ligand 7/monocyte-chemotactic protein 3Tumour-associated fibroblast-driven CCL7 promotes metastasis[51, 52]
Thbs2Thrombospondin-2Cancer cell-derived Thbs2 induces fibroblast activation. Thbs2 promotes bone metastasis in prostate cancer[53, 54]
Adamts5ADAM metallopeptidase with thrombospondin type 1 motif 5Adamts5 overexpression regulates invasion of non-small cell lung cancer[55, 56]
Cyr61Cystein rich angiogenic inducer 61Promotes tumour cell extravasation and metastasis[57]
CtgfConnective tissue growth factorPromotes osteosarcoma angiogenesis[58]
MmdMonocyte to macrophage differentiation proteinRegulates tumour growth in non-small cell lung cancer[59]