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Table 2 Gene expression analysis by IPA software at FC ≥ 1.5 and p value < 0.001 showing the top canonical pathways for each of MWCNT studied

From: Genes expression profiling of alveolar macrophages exposed to non-functionalized, anionic and cationic multi-walled carbon nanotubes shows three different mechanisms of toxicity

Common pathwaysDifferentially regulated pathways
No common pathway between 3 MWCNTNM403NRCWE-042NRCWE-049
Role of Brca1 in DNA damage
Atm signaling
Vitamin-C Transport
Cell cycle: G2/M DNA damage checkpoint regulation
NrF2 mediated oxidative stress response
Common
Mitochondrial dysfunction
EIF2 signaling
Sirtuin signaling
Oxidative phosphorylation
Different
Regulation of eIF4 and p70S6K signalingmTOR signaling
  1. Transcriptomic study was performed using NR8383 cells exposed to ¼ IC50 of each MWCNT for 4 h (N, number of biological replicates = 4). The table shows common and differentially regulated pathways between three CNT