Genes expression profiling of alveolar macrophages exposed to non-functionalized, anionic and cationic multi-walled carbon nanotubes shows three different mechanisms of toxicity

Table 2 Gene expression analysis by IPA software at FC ≥ 1.5 and p value < 0.001 showing the top canonical pathways for each of MWCNT studied

Common pathways	Differentially regulated pathways
No common pathway between 3 MWCNT	NM403	NRCWE-042	NRCWE-049
	Role of Brca1 in DNA damage Atm signaling Vitamin-C Transport Cell cycle: G2/M DNA damage checkpoint regulation NrF2 mediated oxidative stress response	Common
		Mitochondrial dysfunction EIF2 signaling Sirtuin signaling Oxidative phosphorylation
		Different
		Regulation of eIF4 and p70S6K signaling	mTOR signaling

Transcriptomic study was performed using NR8383 cells exposed to ¼ IC₅₀ of each MWCNT for 4 h (N, number of biological replicates = 4). The table shows common and differentially regulated pathways between three CNT

ISSN: 1477-3155