Material | Dose on disk (μg) | ZOI (mm) day 3 | ZOI (mm) day 60 |
---|
Fe3O4 NPs†| 10 | 22/S | 21/S |
5 | 17.5/S | 16/S |
2.5 | 11/R | 10/R |
Fe3O4@PEG NPs | 10 | 0/R | 0/R |
5 | 0/R | 0/R |
2.5 | 0/R | 0/R |
Fe3O4@ALG NPs | 10 | 22/S | 22/S |
5 | 16/S | 15/S |
2.5 | 10/R | 8/R |
Fe3O4@ALG:TOBRA NPs | 10 | 23/S | 22/S |
5 | 11/R | 15/I |
2.5 | 7/R | 5/R |
ZVFe@ALG NPs | 10 | 25/S | 24/S |
5 | 21/S | 22/S |
2.5 | 20/S | 20/S |
Tobramycin | 10* | 10/R | 0/R |
100** | 25/R** | 15/R** |
1000** | 35/R** | 32/R** |
- Interpretation: R resistant, I bintermediate, S susceptible, ZOI zone of inhibition, PEG polyethylene glycol, ALG alginate, TOBRA tobramycin, ZVFe zero-valent iron
- †Uncapped NPs. *CLSI breakpoint for susceptibility of tobramycin by disk diffusion is 10 μg. Therefore, all colonies are found to be tobramycin resistant by CLSI standards. **Higher tobramycin doses in the disk were investigated to determine whether any susceptibility existed at higher doses. At present, there are no CLSI values/breakpoints for NPs as antimicrobial agents