Fig. 10
a The mechanism of MnO2 as a smart chemodynamic agent for enhanced CDT of cancer. Upon endocytosis, the MnO2 can react with intracellular GSH to produce GSSG and Mn2+, which exerts excellent Fenton-like activity to generate highly reactive OH· from endogenous H2O2 in the presence of physiological HCO3-. The impairment of antioxidant defense system (ADS) resulting from GSH depletion makes cancer cells more vulnerable to OH· formed in Mn2+-mediated Fenton-like process, enabling enhanced CDT. b Schematic illustrating the application of MS@MnO2 NPs for MRI-monitored chemo-chemodynamic combination therapy. c H&E-stained images of tumor sections from different groups. Scale bar, 100 μm