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Fig. 14 | Journal of Nanobiotechnology

Fig. 14

From: Multienzymes activity of metals and metal oxide nanomaterials: applications from biotechnology to medicine and environmental engineering

Fig. 14

I The DOX/AT loaded Fe3O4@MSN-TPP/PEG-FA accumulated in the tumor cells by recognition of folate receptors and further targeted to mitochondria by TPP-mediated effect. In this study, excessively toxic OH· which could induce cell death were generated by a series of biochemical reactions. II Evaluation of ROS generating capability of DOX/AT-loaded Fe3O4@MSN-TPP/PEG-FA in vitro. (A) CLSM images of MCF-7 and MGC-803 cells incubated with DOX/AT-loaded Fe3O4@MSN-TPP/PEG-FA for different incubation time. Flow cytometry assay ROS level of MCF-7 cells (B) and MGC-803 cells (C). a, control group; b, DOX/AT-loaded MSN-TPP/PEG-FA; c, DOX/AT-loaded Fe3O4@MSN; d, DOX/AT-loaded Fe3O4@MSN-TPP/PEG-FA. (D) The analysis of flow cytometry. (n = 3). *P < 0.05 and **P < 0.01

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