Modular vaccine platform based on the norovirus-like particle

Table 1 Vaccine groups and doses used in the immunization experiment

Group	Mice/group (n)	Vaccine	Total protein dose (µg)	Antigen^a dose (µg)	Endotoxin dose (EU)
I	4	SpyTag-noro-VLP^b	25	24.3	< 1
II	4	SpyCatcher-HA2	25	12.5	< 0.4
III	5	HA2-noro-VLP	15	1.3	< 0.6
IV	4	SpyCatcher-M2e	100	24.3	< 5.4
V	5	M2e-noro-VLP	50	1.2	< 0.4

^aThe dose of the underlined antigen molecule is estimated in this column, as described in the text
^bNorovirus-like particle

ISSN: 1477-3155