Fig. 4
From: Tailored liposomal nanotraps for the treatment of Streptococcal infections
Inhibition of secreted hemolysins of GAS and GGS supernatants or recombinant SLO by liposomes composed of PC or Sm. Liposomes composed of PC provide partial protection against hemolytic activities of all GGS and GAS ATCC supernatants and no protection against GAS 50362 and GAS 31009 supernatants (a, d). Sm-liposomes inhibit recombinant SLO, whereas PC-liposomes provide no protection (b). Liposomes composed of Sm provide full protection against GGS 5804 supernatant, partial protection against GGS 5109, GGS ATCC 12394 and GAS ATCC 19165 supernatants and no protection against GAS 50362 and GAS 31009 supernatants (c, e). However, the full neutralization of GAS/GGS hemolysins is achieved by the combination of either PC- or Sm-liposomes with Ch:Sm-liposomes (f, g). Likewise, combined within single liposome, Ch and PC (Ch:PC-liposomes) provide full protection against hemolytic activities of all GAS/GGS supernatants (h, i). Error bars = Mean ± SD. N ≥ 3