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Table 1 Proteins involved in an important biological process found to be differentially regulated by MSN15, MWCNT5 and ZnO5 nanoparticles

From: MSN, MWCNT and ZnO nanoparticle-induced CHO-K1 cell polarisation is linked to cytoskeleton ablation

Biological Process

Protein name

MSN15/control

ZnO5/control

MWCNT5/control

Clathrin mediated Endocytosis

SRP-9

Snap91,

AP-2

Clathrin heavy chain 1

Siglec-1

Dynamin

ARF-6

Arp2/3

2.88

3.33

4.28

2.9

2.63

2.9

2.23

2.27

4.33

2.44

2.28

1.8

1.72

2.36

1.30

2.36

2.88

3.88

6.42

4.1

3.72

2.72

3.15

3.09

ER-mediated

Phagocytosis

Coronin-1A

F-actin

Sec22

MHC1

TAP

CALR

Calnexin

9.5

2.16

1.26

1.5

2.75

4.5

2.7

2

1.16

1.4

0.68

3.62

2.14

1.9

11.5

3.16

2.46

1.36

5.1

6.4

4.1

Early Endosome

Rab7

TfR

vATPase

TAP

CALR

Calnexin

AP-2

4.5

4.7

5.71

2.75

4.5

2.7

2.8

2.87

2.42

2.41

3.62

2.14

1.9

2.1

4.12

6

5.28

5.1

6.4

4.1

3.9

Late Endosome

Rab5

TUBA

TUBB

Stx7

AP-3

2.45

3.75

5.83

1.54

3.6

1.81

1.75

1.16

2.09

2.1

3.45

5.37

8

4.36

5.8

Lysosome

LAMP

Cathepsin

M6PR

2.63

3

3.11

1.90

1.8

3

3.36

4.1

4

Autophagy

VPS29

Cathepsin D

Cathepsin B

LAMP

ATG12

ATG16

Frizzled-8

4

3

1.22

3.77

1.64

3.87

2.6

2

1.8

0.77

1.88

0.35

2.25

1.27

5.3

4.1

2.17

4.33

2.88

5.25

3.18

DNA Damage and Repair associated proteins

Brat1

ATR protein kinase

Tp53

Pidd1

Tp53i13

Tp53tg5

CDK1

CDK2

CDK13

Rbbp6

Garem2

GRB10

GRB2

Mus81

Igfbp3

3.36

2.54

2

1.56

4

1.22

1.21

4.42

7

0.69

5.85

4.22

8.5

1.61

2.88

1.36

2.09

2.4

2.31

3.25

1.5

2.5

2.57

3.33

0.5

2

0.66

8.5

0.83

2.33

3.36

3.45

4.6

1.31

4.25

1.77

2.5

5.17

4.16

1.38

5.28

5.22

7

2.11

4.55

Cytoskeleton Network Modulator

CALPAIN-2

CALPAIN-10

CALPAIN-6

CALPAIN-11

Dlc1

Dock3

Rac1

Pak1

Cofilin-1

Dynamin-1

Arp 2/3 complex

Coronin-1A

Rock2

UBXN11

CMFR1

Neurabin-2

Plexin-B1

WASF

CDC42bpd

Ppp1r11

Ppp1r32

NTRK2

Alpha-actinin-4

2

2.9

0.92

3.1

10.25

1

3

3.4

4.33

1.69

10.5

9.5

2

1.4

2.2

5

3.11

2.6

4.85

5.2

2.1

4.83

3.22

2.27

1.8

0.84

1.5

2.75

0.53

2.66

1.7

3.33

2

1.25

2

2.63

7

2.8

1.42

2.77

1.9

2.71

0.71

0.63

3.5

1.5

3.54

4.3

1.11

4.2

11

4.06

4

3.6

8

3.07

12.25

11.75

3.45

0.6

2.9

5.85

4.2

4.2

4.71

7.14

1.5

7.3

4.5