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Fig. 7 | Journal of Nanobiotechnology

Fig. 7

From: Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small‐molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids

Fig. 7

Effect of siEphA2 complexes and JIB-04 on cell viability of PC-3 cells. a Viability (left) and dose-response curve (right) of PC-3 cells after JIB-04 treatment for 48 h. The results are presented as mean ± SD. Asterisks represent statistical significance (*p < 0.05, ***p < 0.001, one-way ANOVA followed by Sidak’s test, n = 3). The effect of siEphA2 complexes co-administered with JIB-04 on cell viability in PC-3 cells cultured as monolayer cells (2D; 48 h) (b) and spheroids (3D; 96 h) (c). The results are given as the mean ± SD (UT: Untreated control, ns: not significant, **p < 0.01, ***p < 0.001, one-way ANOVA followed by Tukey’s test; n = 4 for 2D, n = 3 for 3D)

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Journal of Nanobiotechnology

ISSN: 1477-3155

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