Skip to main content

Table 2 Statistical ANOVA analysis of Quadratic model

From: pH-responsive delivery vehicle based on RGD-modified polydopamine-paclitaxel-loaded poly (3-hydroxybutyrate-co-3-hydroxyvalerate) nanoparticles for targeted therapy in hepatocellular carcinoma

Source Sum of square Degree of freedom Mean square F-value p-value b  
Modela 30,567.71 13 2351.36 302.94  < 0.0001  
X1 591.56 1 591.56 76.22  < 0.0001  
X2 5962.07 1 5962.07 768.14  < 0.0001  
X3 2884.03 1 2884.03 371.57  < 0.0001  
X4 3828.79 1 3828.79 493.29  < 0.0001  
X1 X2 835.21 1 835.21 107.61  < 0.0001  
X1 X3 1451.61 1 1451.61 187.02  < 0.0001  
X1 X4 430.56 1 430.56 55.47  < 0.0001  
X2 X4 115.56 1 115.56 14.89 0.0014  
X3 X4 637.56 1 637.56 82.14  < 0.0001  
X12 615.60 1 615.60 79.31  < 0.0001  
X22 6685.72 1 6685.72 861.37  < 0.0001  
X32 5366.40 1 5366.40 691.39  < 0.0001  
X42 7433.52 1 7433.52 957.72  < 0.0001  
Credibility analysis of the regression equations
Standard deviation Mean Coefficient of variation R2 Adjust R2 Predicted R2 Adequacy precision
2.79 120.81 2.31 0.996 0.9927 0.9819 57.161
  1. The results were obtained with Design Expert 8.0 software
  2. a X1: water–oil ratio; X2: PHBV content (%); X3: PVA content (%); X4: homogenization time (min); Y: particle size (nm)
  3. b p-value < 0.05 consider as statistically significant