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Table 2 Statistical ANOVA analysis of Quadratic model

From: pH-responsive delivery vehicle based on RGD-modified polydopamine-paclitaxel-loaded poly (3-hydroxybutyrate-co-3-hydroxyvalerate) nanoparticles for targeted therapy in hepatocellular carcinoma

Source

Sum of square

Degree of freedom

Mean square

F-value

p-value b

 

Modela

30,567.71

13

2351.36

302.94

 < 0.0001

 

X1

591.56

1

591.56

76.22

 < 0.0001

 

X2

5962.07

1

5962.07

768.14

 < 0.0001

 

X3

2884.03

1

2884.03

371.57

 < 0.0001

 

X4

3828.79

1

3828.79

493.29

 < 0.0001

 

X1 X2

835.21

1

835.21

107.61

 < 0.0001

 

X1 X3

1451.61

1

1451.61

187.02

 < 0.0001

 

X1 X4

430.56

1

430.56

55.47

 < 0.0001

 

X2 X4

115.56

1

115.56

14.89

0.0014

 

X3 X4

637.56

1

637.56

82.14

 < 0.0001

 

X12

615.60

1

615.60

79.31

 < 0.0001

 

X22

6685.72

1

6685.72

861.37

 < 0.0001

 

X32

5366.40

1

5366.40

691.39

 < 0.0001

 

X42

7433.52

1

7433.52

957.72

 < 0.0001

 

Credibility analysis of the regression equations

Standard deviation

Mean

Coefficient of variation

R2

Adjust R2

Predicted R2

Adequacy precision

2.79

120.81

2.31

0.996

0.9927

0.9819

57.161

  1. The results were obtained with Design Expert 8.0 software
  2. a X1: water–oil ratio; X2: PHBV content (%); X3: PVA content (%); X4: homogenization time (min); Y: particle size (nm)
  3. b p-value < 0.05 consider as statistically significant
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Journal of Nanobiotechnology

ISSN: 1477-3155

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