Fig. 4
Biodegradation and In vivo Safety Assessment of DATS@MION-PEG-LF. a Coronal view of mouse by MRI scan, the hepatic, brain, and heart religion were selected for detecting fluorescence intensity (red circle). b Time course assessment of DATS@MION-PEG-LF intensity in mice by fluorescence intensity assessment, compared with the untreated mice (Normal). c Toxicity assessment of DATS@MION-PEG-LF via H&E staining in vital organs. d Heart rates and e mean blood pressure in 12 h after injection. f H2S concentration in plasma after injection of DATS@MION-PEG-LF at different doses. (mean ± SEM, n = 6)