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Fig. 8 | Journal of Nanobiotechnology

Fig. 8

From: Novel fusion peptide‐mediated siRNA delivery using self‐assembled nanocomplex

Fig. 8

In vivo gene silencing effect using fluorescence imaging. 5.0 × 106 cells of pmCherry-N1 transfected HEK293T with 4 µg of free mCherry-siRNA (left) and siRNA/S-R11 nanocomplex (right) were inoculated subcutaneously on both back sides of the BALB/c nude mice. a The mCherry fluorescence intensity was observed on day 0 and day 1 using an in vivo fluorescence imaging system. The left arrow indicated the fluorescence of mCherry-expressing cells with free siRNAs, and the right arrow pointed to that of the S-R11 nanocomplex. b Relative integrated density of each mice was analyzed using the NEOimage software. The relative integrated intensity was calculated by that integrated intensity at day 1 was divided by that at day 0. The data represented mean ± standard deviation (*p < 0.05 and independent n = 4)

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