Fig. 6
From: Gold nanoparticles reduce inflammation in cerebral microvessels of mice with sepsis
Effect of citrate-covered gold nanoparticles (cit-AuNP) on phosphorylated and total inhibitor κBα (IκBα) in brain. Twenty nanometers cit-AuNP or saline was injected intravenously (IV) 2 h after induction of sepsis or the sham-operated procedure in mice. Representative blots (upper panel) and quantification of the phosphorylated IκBα (phospho-IκBα) (middle panel) and total IκBα (lower panel) expressions in brain of mice with sepsis or sham-operated previously treated with saline or cit-AuNP. Enhanced phospho-IκBα, but not total IκBα, was demonstrated in brain of mice 6 h after induction of sepsis, but that increase was not observed in mice previously treated with cit-AuNP. * P < 0.05 vs. Sham + saline. ANOVA followed by Tukey’s test was used for comparison among groups. Four to five animals per group were used. n. s., not significant; a. u., arbitrary units