Fig. 7
From: Gold nanoparticles reduce inflammation in cerebral microvessels of mice with sepsis
Effect of citrate-covered gold nanoparticles (cit-AuNP) and imipenem and cilastatin on the survival rate. Twenty nanometers cit-AuNP or saline was injected intravenously (IV) 2 h and 24 h (named one day − 1d −) after induction of sepsis or the sham-operated procedure in mice, and 0.3 mg imipenem and 0.6 mg cilastatin, per animal, were injected twice a day for three days (3d), starting 2 h after induction of sepsis and at 12 h intervals afterwards. Cit-AuNP alone (a) or combined with imipenem and cilastatin (b) did not change the survival rate of mice with sepsis. * P < 0.05 vs. Sham + saline. Log-rank (Mantel-Cox) test was used for comparison of survival curves. Five to six animals per group were used. n. s., not significant