Fig. 1

Environmental sensitivity, inhibition of cell migration and biocompatibility of the NPs composed of different PEG-HA ratios. a Environmentally sensitive changes in particle size associated with mPEG and the o-HA block ratio. b Environmentally sensitive changes in zeta potential associated with mPEG and the o-HA block ratio. c Environmentally sensitive release profile of PTX from the NPs (upper, different pH environments; lower, different GSH environments). d Environmentally sensitive release profile of miR124 from the NPs (upper, different pH environments; lower, different GSH environments). e Effects of different treatments for 24 h (upper) and 48 h (lower) on the migration of MDA-MB-231 cells. (f) Biocompatibility of the NPs composed of the 3 materials in LO2 cells. *p < 0.05, **p < 0.01