Fig. 5

Therapeutic efficiency of PTX/miR124-NP in mice bearing MDA-MB-231 tumours. a Fluorescence images of mice at 2, 4, 8, 24 and 48 h after the intravenous injection of free Dir and Dir-NP. b Ex vivo fluorescence images of tumours and major organs 48 h after administration. c Quantified fluorescence intensity of the tumour and major organs (MFI, mean fluorescence intensity). d Images of tumours at the end of treatment (n = 6 for all groups). e The profiles of variations in the tumour volumes. f Tumour inhibition rate. g TUNEL analysis of tumour cell apoptosis. The green dot represents apoptotic cells. h Representative images of lung tissue sections from different treatment groups evaluated using H&E staining. i Quantitative analysis of the pulmonary metastatic nodules