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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: Administration route governs the therapeutic efficacy, biodistribution and macrophage targeting of anti-inflammatory nanoparticles in the lung

Fig. 2

The effect of administration routes on cell infiltration in the BALF in the LPS-induced ALI mouse with a lower dose of P12. a A schematic diagram of LPS-induced ALI model with the pretreatment of P12 (50 μL, 125 nM) or the same volume of PBS through i.t., i.v. or i.p. administration 2 h before LPS (10 mg/kg, i.t.) challenge. Mice were sacrificed to harvest the BALF 24 h after LPS injection for the analysis of the number of total cells (b), neutrophils (c), macrophages (d) and lymphocytes (e). N ≥ 6 per group, ns: not significant, *p < 0.05, **p < 0.01

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