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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Administration route governs the therapeutic efficacy, biodistribution and macrophage targeting of anti-inflammatory nanoparticles in the lung

Fig. 4

The effect of the administration routes of P12 on the lung inflammation and injury in LPS-induced ALI mice. a Representative histological images (× 200) of lung sections with hematoxylin and eosin (H&E) staining from PBS + PBS, PBS + LPS, P12 (125 nM) + LPS and P12 (500 nM) + LPS groups; Mice were pretreated P12 through i.t., i.p. or i.v. administration, followed by intratracheal instillation of LPS. Scale bar = 100 µm. b Lung injury scores of the lung sections from each group for two different P12 concentrations (125 nM at left; 500 nM at right). N = 6 per group, ns: not significant, **p < 0.01, ***p < 0.001

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