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Fig. 9 | Journal of Nanobiotechnology

Fig. 9

From: A sonosensitiser‐based polymeric nanoplatform for chemo‐sonodynamic combination therapy of lung cancer

Fig. 9

In vivo anti-tumour effect in a bilateral A549 mouse model. a Overall schedule of in vivo tumour inhibition study. (bd) RTV curves of ‘R’ (b) and ‘L’ (c) tumours and body weight curves (d). e Photographs of ‘R’ and ‘L’ tumours after autopsy. f Western blot result of expression of COX-2 and uPA proteins after treatment with different solutions at day 15. g and h H&E staining images of ‘R’ (g) and ‘L’ (h) tumour tissues after the treatment with NS, C-NPs (SDT+), Taxotere®, DTX + Rh, DTX/C-NPs (SDT + or SDT-). Scale bar denotes 100 µm. i TUNEL results of ‘R’ tumours from all bilateral tumour-bearing mice treated with NS, C-NPs (SDT+), Taxotere®, DTX + Rh and DTX/C-NPs (SDT + or SDT-). Scale bar denotes, 100 µm. **p < 0.01, ***p < 0.001

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