Fig. 8

Exosomal miR-133a-3p inhibited cardiomyocyte apoptosis, promoted angiogenesis by AKT signal pathway, and improved the protein expression of VEGF in HUVECs. The protein levels of p-AKT, AKT, Bcl-2, cleaved caspase-3 and VEGF in HUVECs (a), and quantification analysis (c). (n = 3 biological replicates). The protein levels of p-AKT, AKT, Bcl-2, and cleaved caspase-3 in H9C2 cells (b), and quantification analysis (d). (n = 3 biological replicates). Continuous variables and categorical variables were described by means ± SEM and percentages. *P < 0.05; **P < 0.01; ****P < 0.0001. e Schematic showed the working model of this study