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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Nanotechnology against human cytomegalovirus in vitro: polyanionic carbosilane dendrimers as antiviral agents

Fig. 6

Virucidal activity of G2-S16 or G2-S24P dendrimers against HCMVAD−169. Plaque reduction assays were performed in MRC-5 cells for 6 days treatments. G2-S16 or G2-S24P dendrimer at 10 µM was incubated with 60 PFU for 2 h at 37 ºC. By several centrifugations at 12,000 RPM virus was pelleted, resuspended in fresh DMEM and added to MRC-5 cells for plaque reduction assays. Plaques were counted after 6 days with a methylene blue dye. Percentage of HCMVAD−169 infection is represented as the number of plaques in treatments in regard of the control of infection. Triton X-100 was used as a positive control of virus membrane disruption. CI: Control of Infection, NT: non-treated control. The mean values (mean ± SD) of at least four independent experiments are shown (*p < 0.05; **p < 0.005; ***p < 0.001)

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