Fig. 5

Biodistribution of SiNP in vivo and pathological changes of the uterus. The pregnant C57BL/6 mice were intratracheally instilled with 50 µL of FITC-SiNP at 5 mg/mL and observed using a live animal imaging system at 0, 4, 8, 16, 24 h. a Images showing the biodistribution and accumulation of FITC-SiNP in mice and their dissected uteri. b, c Quantitative analysis of the integrated fluorescence intensity at different observation time points, where it decreased as a whole in a time-depedent manner but increased in the uteri. d Images showing the pathological changes of the uteri. The infiltration of inflammatory cells exacerbated after SiNP exposure. e Boxplot showing the increased number of inflammatory cells in the uteri. f Forrest plot showing the comparison of inflammatory cells between different observation time points. The differences were compared using one-way ANOVA followed by SNK post-hoc test. *P < 0.05