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Fig. 1 | Journal of Nanobiotechnology

Fig. 1

From: Development of a chitosan‐modified PLGA nanoparticle vaccine for protection against Escherichia coli K1 caused meningitis in mice

Fig. 1

Chitosan-modified PLGA nanoparticles are suitable for the formulation of Vo nanoparticles. a The size distribution of nanoparticles from five formulations. S1: Chitosan nanoparticles; S2: PLGA nanoparticles with dichloromethane as a solvent; S3: PLGA nanoparticles with acetone as a solvent; S4: Chitosan nanoparticles modified with PLGA; S5: PLGA nanoparticles modified with chitosan (CS-PLGA). b The polydispersity index (PDI) of nanoparticles from the five formulations. c Scanning electron microscopy observation of nanoparticles from the five formulations. d The size distribution of CS-PLGA nanoparticles loaded with a gradient of recombinant Vo. e The PDI of CS-PLGA nanoparticles loaded with a gradient of concentrations of recombinant Vo. f Entrapment efficiency of CS-PLGA nanoparticles loaded with a gradient of concentrations of recombinant Vo. *P < 0.05

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Journal of Nanobiotechnology

ISSN: 1477-3155

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