Fig. 5From: Development of a chitosan‐modified PLGA nanoparticle vaccine for protection against Escherichia coli K1 caused meningitis in mice The VoNPs were nontoxic to L929 cells and mice. a Morphological changes in the L929 cells cultured in the presence of the VoNPs or blank nanoparticles (BNPs). b The optical density of cells cultured in the presence of VoNPs or BNPs. n.s. no significant difference; *P < 0.05. c Histological changes in the heart, liver, spleen, lungs and kidneys of mice injected with the VoNPs or BNPsBack to article page