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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Development of a chitosan‐modified PLGA nanoparticle vaccine for protection against Escherichia coli K1 caused meningitis in mice

Fig. 5

The VoNPs were nontoxic to L929 cells and mice. a Morphological changes in the L929 cells cultured in the presence of the VoNPs or blank nanoparticles (BNPs). b The optical density of cells cultured in the presence of VoNPs or BNPs. n.s. no significant difference; *P < 0.05. c Histological changes in the heart, liver, spleen, lungs and kidneys of mice injected with the VoNPs or BNPs

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