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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Sialic acid-engineered mesoporous polydopamine dual loaded with ferritin gene and SPIO for achieving endogenous and exogenous synergistic T2-weighted magnetic resonance imaging of HCC

Fig. 5

a Western blot study of AFP between HepG2 and LO2. b Ferritin level of HepG2 that transfected by MPDA@SPIO/SA-PEI/AFP-Fth, MPDA@SPIO/PEI/AFP-Fth, SA-PEI/AFP-Fth. Free AFP-Fth was also added as control group. c T2-weighted images of transfected HepG2 cells with or without FAC supplement, and the chart of 1/T2 (S−1) values. d The tumor model made in orthotopic injection HepG2 cells, the yellow cycle stands for tumor in liver. Microscope image (× 10) of HE and Ki-67 immunofluorescence stained liver tissue section, “L” indicated the normal liver, “T” indicated the tumor tissue. (a, MPDA@SPIO/SA-PEI/AFP-Fth b, MPDA@SPIO/PEI/AFP-Fth c, SA-PEI/AFP-Fth d, AFP-Fth) (n = 5; ***p < 0.001, **p < 0.01, *p < 0.05, compared with untreated cells)

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Journal of Nanobiotechnology

ISSN: 1477-3155

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