Central composite design for the development of carvedilol-loaded transdermal ethosomal hydrogel for extended and enhanced anti-hypertensive effect

Table 5 Regression values of the selected responses during optimization

Model	Y₁			Y₂			Y₃
Model	\({\mathrm{R}}_{\mathrm{O}}^{2}\)	\({\mathrm{R}}_{\mathrm{A}}^{2}\)	\({\mathrm{R}}_{\mathrm{P}}^{2}\)	\({\mathrm{R}}_{\mathrm{O}}^{2}\)	\({\mathrm{R}}_{\mathrm{A}}^{2}\)	\({\mathrm{R}}_{\mathrm{P}}^{2}\)	\({\mathrm{R}}_{\mathrm{O}}^{2}\)	\({\mathrm{R}}_{\mathrm{A}}^{2}\)	\({\mathrm{R}}_{\mathrm{P}}^{2}\)
Linear	0.6611	0.5976	0.4484	0.3675	0.2489	0.0766	0.5597	0.4771	0.2359
2FI	0.7666	0.6588	0.5264	0.6574	0.4993	0.3302	0.8434	0.7711	0.6347
Quadratic	0.9890	0.9790	0.9203	0.9887	0.9785	0.9318	0.9662	0.9358	0.9025
p value	0.0001			0.0001			0.0001

ISSN: 1477-3155